Publications :

2009

Nikhil V. Munshi, John McAnally, Svetlana Bezprozvannaya, Jeff M. Berry, James A. Richardson, Joseph A. Hill, Eric N. Olson; Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay; Development, 13615):26665-74, 2009

Erin E. Yund, Joseph A. Hill, Rebecca S. Keller; Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes; J Mol Cell Cardiol, 47(4):520-27, 2009

Samvit Tandan, Yanggan Wang, Thomas T. Wang, Nan Jiang, Duane D. Hall, Johannes W. Hell, Xian Luo, Beverly A. Rothermel, Joseph A. Hill; Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca2+ Channel; Cir Res, 105(1):51-60, 2009

Johannes Backs, Thea Backs, Stefan Neef, Michael M. Kreusser, Lorenz H. Lehmann, David M. Patrick, Chad E. Grueter, Xiaoxia Qi, James A. Richardson, Joseph A. Hill, Hugo A. Katus, Rhonda Bassel-Duby, Lars S. Maier, Eric N. Olson; The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload; Proc Natl Acad Sci, 106(7):2342-7, 2009

Hongxin Zhu, Beverly A. Rothermel, Joseph A. Hill; Autophagy in load-induced heart disease; Meth Enzymol, 453:343-63, 2009

2008

Beverly A Rothermel, Joseph A Hill; Autophagy in load-induced heart disease; Circ Res, 103(12):1363-1369, 2008

Beverly A Rothermel, Joseph A Hill; Adenosine A3 receptor and cardioprotection: enticing, enigmatic, elusive; Circulation, 118(17):1691-1693, 2008

Beverly A Rothermel, Joseph A Hill; The heart of autophagy: deconstructing cardiac proteotoxicity; Autophagy, 4(7):932-935, 2008

Yanggan Wang, Samvit Tandan, Jun Cheng, Chunmei Yang, Lan Nguyen, Jessica Sugianto, Janet L Johnstone, Yuyang Sun, Joseph A Hill; Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure; J Biol Chem, 283(37):25524-25532, 2008

Eva van Rooij, Lillian B Sutherland, Jeffrey E Thatcher, J Michael DiMaio, R Haris Naseem, William S Marshall, Joseph A Hill, Eric N Olson; Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis; Proc Natl Acad Sci USA, 105(35):13027-13032, 2008

Shusheng Wang, Arin B Aurora, Brett A Johnson, Xiaoxia Qi, John McAnally, Joseph A Hill, James A Richardson, Rhonda Bassel-Duby, Eric N Olson; The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis; Dev Cell, 15(2):261-271, 2008

Paul Tannous, Hongxin Zhu, Janet L Johnstone, John M Shelton, Namakkal S Rajasekaran, Ivor J Benjamin, Lan Nguyen, Robert D Gerard, Beth Levine, Beverly A Rothermel, Joseph A Hill; Autophagy is an adaptive response in desmin-related cardiomyopathy; Proc Natl Acad Sci USA, 105(28):9745-9750, 2008

Paul Tannous, Hongxin Zhu, Andriy Nemchenko, Jeff M Berry, Janet L Johnstone, John M Shelton, Francis J Miller, Beverly A Rothermel, Joseph A Hill; Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy; Circulation, 117(24):3070-3078, 2008

Joseph A Hill, Eric N Olson; Cardiac plasticity; N Engl J Med, 358(13):1370-1380, 2008

Mounir Errami, Cristi L Galindo, Amina T Tassa, John M Dimaio, Joseph A Hill, Harold R Garner; Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice; J Pharmacol Exp Ther, 324(3):1196-1203, 2008

Jens Fielitz, Mi-Sung Kim, John M Shelton, Xiaoxia Qi, Joseph A Hill, James A Richardson, Rhonda Bassel-Duby, Eric N Olson; Requirement of protein kinase D1 for pathological cardiac remodeling; Proc Natl Acad Sci, 105(8):3059-3063, 2008

Beverly A Rothermel, Joseph A Hill, et. al.; Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes; Autophagy, 4(2):151-175, 2008

Yuri Kim, Dillon Phan, Eva van Rooij, Da-Zhi Wang, John McAnally, Xiaoxia Qi, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson; The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice; J Clin Invest, 118(1):124-132, 2008

Jeff M Berry, Dian J Cao, Beverly A Rothermel, Joseph A Hill; Histone deacetylase inhibition in the treatment of heart disease; Expert Opinion on Drug Safety, 7(1):53-67, 2008

2007

Hongxin Zhu, Paul Tannous, Janet L Johnstone, Yongli Kong, John M Shelton, James A Richardson, Vien Le, Beth Levine, Beverly A Rothermel, Joseph A Hill; Cardiac autophagy is a maladaptive response to hemodynamic stress; J Clin Invest, 117:1782-93, 2007

Yanggan Wang, Jun Cheng, Guohua Chen, Farhana Rob, R. Haris Naseem, Lan Nguyen, Janet L. Johnstone, Joseph A. Hill; Remodeling of Outward K(+) Currents in Pressure-Overload Heart Failure; J Cardiovasc Electrophysiol, 2007

Koichiro Kuwahara, Gordon C Teg Pipes, John McAnally, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson; Modulation of Adverse Cardiac Remodeling by STARS, a Mediator of MEF2 Signaling and SRF Activity; J Clin Invest, 117:1324-34, 2007

Chengcheng Shen, Mei-Jung Lin, Alp Yarandanakul, Vincenzo Lariccia, Joseph A. Hill, Donald W. Hilgemann; Dual Control of Cardiac Na/Ca Exchange by PIP2: Analysis of the Surface Membrane Fraction by Extracellular Cysteine PEGylation; J Physiol, 2007

2006

Koichiro Kuwahara, Yanggan Wang, John McAnally, James A Richardson, Rhonda Bassel-Duby, Joseph A Hill, Eric N Olson; TRPC6 Fulfills a Calcineurin Signaling Circuit During Pathologic Cardiac Remodeling; J Clin Invest, 116;3114-26, 2006

Yanggan Wang, Jun Cheng, Samvit Tandan, Minjie Jiang, Diana T McCloskey, Joseph A Hill; Transient-outward K+ Channel Inhibition Facilitates L-type Ca2+ Current in Heart; J Cardiovasc Electrophysiol, 17:298-304, 2006

Kunhua Song, Johannes Backs, John McAnally, Xiaoxia Qi, Robert D Gerard, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson; The Transcriptional Coactivator CAMTA2 Stimulates Cardiac Growth by Opposing Class II Histone Deacetylases; Cell, 125:453-66, 2006

Yongli Kong, Paul Tannous, Guangrong Lu, Kambeez Berenji, Beverly A Rothermel, Eric N Olson, Joseph A Hill; Suppression of Class I and II Distone Deacetylases Blunts Pressure-overload Cardiac Hypertrophy; Circulation, 113:2579-88, 2006

Yanggan Wang, Jun Cheng, Ronald W Joyner, Mary B Wagner, Joseph A Hill; Remodeling of Early-phase Repolarization: A Mechanism of Abnormal Impulse Conduction in Heart Failure; Circulation, 113:1849-56, 2006

Yanggan Wang, Joseph A Hill; Human atrial chloride channels: swelling with pride; J Cardiovasc Electrophysiol, 17;69-71, 2006

Yan G Ni, Kambeez Berenji, Na Wang, Misook Oh, Nita Sachan, Asim Dey, Jun Cheng, Guangrong Lu, David J Morris, Diego H Castrillon, Robert D Gerard, Beverly A Rothermel, Joseph A Hill; Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling; Circulation, 114:1159-68, 2006

2005

Joseph A Hill; In Vino Veritas: Alcohol and Heart Disease; Am J Med Sci, 329:124-35, 2005

Kenneth E Richardson, Paul Tannous, Kambeez Berenji, Bridgid Nolan, Kayla J Bayless, George E Davis, Beverly A Rothermel, Joseph A Hill; Guanosine Triphosphatase Activation Occurs Downstream of Calcineurin in Cardiac Hypertrophy; J Investig Med, 53:414-24, 2005

Kambeez Berenji, Mark H Drazner, Beverly A Rothermel, Joseph A Hill;
Does Load-induced Ventricular Hypertrophy Progress to Systolic Heart Failure?; Am J Physiol Heart Circ Physiol, 289:H8-H16, 2005

Beverly A Rothermel, Kambeez Berenji, Paul Tannous, William Kutschke, Asim Dey, Bridgid Nolan, Ki-Dong Yoo, Elaine Demetroulis, Michael Gimbel, Barry Cabuay, Mohsen Karimi, Joseph A Hill; Differential Activation of Stress-Response Signaling in Load-Induced Cardiac Hypertrophy and Failure; Physiol Genomics, 23:18-27, 2005

Misook Oh, Igor I Rybkin, Victoria Copeland, Michael P Czubryt, John M Shelton, Eva van Rooij, James A Richardson, Joseph A Hill, Leon J De Windt, Rhonda Bassel-Duby, Eric N Olson, Beverly A Rothermel; Calcineurin is Necessary for the Maintenance but not Embryonic Development of Slow Muscle Fibers; Mol Cell Biol, 25:6629-38, 2005

2004

Norbert Frey, Tomasa Barrientos, John M Shelton, Derk Frank, Hartmut Rütten, Doris Gehring, Christian Kuhn, Matthias Lutz, Beverly Rothermel, Rhonda Bassel-Duby, James A Richardson, Hugo A Katus, Joseph A Hill, Eric N Olson; Mice Lacking Calsarcin-1 Are Sensitized to Calcineurin Signaling and Show Accelerated Cardiomyopathy in Response to Pathological Biomechanical Stress; Nat Med, 10:1336-43, 2004

Norbert Frey, Hugo A Katus, Eric N Olson, Joseph A Hill; Hypertrophy of the Heart: a New Therapeutic Target?; Circulation, 109:1580-9, 2004

Shurong Chang, Timothy A McKinsey, Chun Li Zhang, James A Richardson, Joseph A Hill, Eric N Olson; Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development; Mol Cell Biol, 24:8467-76, 2004

2003

Joseph A Hill; Electrical Remodeling in Cardiac Hypertrophy; Trends Cardiovasc Med, 13:316-22, 2003

Brian Palen, William Stanford, Thomas Fagan, Joseph A Hill; Atypical Chest Pain and Atypical Coronary Artery Disease; Am J Cardiol, 92:120, 2003

Chien-Chang Chen, Kathryn G Lamping, Daniel W Nuno, Rita Barresi, Sally J Prouty, Julie L Lavoie, Leanne L Cribbs, Sarah K England, Curt D Sigmund, Robert M Weiss, Roger A Williamson, Joseph A Hill, Kevin P Campbell; Abnormal Coronary Function in Mice Deficient in Alpha1H T-Type Ca2+ Channels; Science, 302:1416-8, 2003

2002

Joseph A Hill, Beverly Rothermel, Ki-Dong Yoo, Barry Cabuay, Elaine Demetroulis, Robert M Weiss, William Kutschke, Rhonda Bassel-Duby, R Sanders Williams; Targeted Inhibition of Calcineurin in Pressure-overload
Cardiac Hypertrophy
; J Biol Chem, 277:10251-5, 2002

Francisco J Naya, Brian L Black, Hai Wu, Rhonda Bassel-Duby, James A Richardson, Joseph A Hill, Eric N Olson; Mitochondrial deficiency and cardiac sudden death in mice
lacking the MEF2A transcription factor
; Nat Med, 8:1303-9, 2002

Chun Li Zhang, Timothy A McKinsey, Shurong Chang, Christopher L Antos, Joseph A Hill, Eric N Olson; Class II Histone Deacetylases Act as Signal- Responsive Repressors of Cardiac Hypertrophy; Cell, 110:479-88, 2002

Christopher L Antos, Timothy A McKinsey, Norbert Frey, William Kutschke, John McAnally, John M Shelton, James A Richardson, Joseph A Hill, Eric N Olson; Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo; Proc Natl Acad Sci USA, 99:907-12, 2002

2001

B London, W Guo, Pan Xh, J S Lee, V Shusterman, C J Rocco, D A Logothetis, J M Nerbonne, J A Hill; Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine–Sensitive Component of Ik,slow and Resistance to Drug-Induced QT Prolongation; Circ Res, 88:940-6, 2001

Z Wang, B Nolan, W Kutschke, J A Hill; Sodium-Calcium Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy; J Biol Chem, 276:17706-11, 2001

Z Wang, W Kutschke, K E Richardson, M Karimi, J A Hill; Electrical Remodeling in Pressure-Overload Cardiac Hypertrophy (Role of Calcineurin); Circulation, 104:1657-63, 2001

2000

J A Hill, R E Kerber; Quo Vadis? How Should We Train Cardiologists at the Turn of the Century?; Circulation, 102:932-936, 2000

Joseph A Hill; Deconstructing cardiac hypertrophy: signaling pathways involved in structural, functional and electrical remodeling; Current Opinion in Cardiovascular, Pulmonary & Renal Investigational Drugs, 2:25-9, 2000

J A Hill, M Karimi, W Kutschke, R L Davisson, K Zimmerman, Z Wang, R E Kerber, R M Weiss; Cardiac Hypertrophy Is Not a Required Compensatory Response to Short-Term Pressure Overload; Circulation, 101:2863-9, 2000